Table 2

Several individual DNA methylation markers are associated with survival

Statistics

KRT19

FAS

CNR1

HIST1H3C

ACSS3

GNAS


HR-DOD versus LR-SURV (P-value OS)

0.037

0.028

0.043

0.002

0.002

0.012

HR-DOD versus LR-SURV (P-value EFS)

0.039

0.049

0.039

0.039

0.079

0.039

HR-DOD versus LR-SURV and HR-SURV (P-value OS)

0.687

0.639

0.423

0.039

0.691

0.221

HR-DOD versus LR-SURV and HR-SURV (P-value EFS)

0.665

0.467

0.414

0.041

0.939

0.041

HR-DOD versus LR-SURV and HR-SURV (P-value OS (stratum))

Age < 12 months 0.035

Stage 4 0.033

MYCN = 0 0.033

HR-DOD versus LR-SURV and HR-SURV (P-value EFS (stratum))

Age < 12 months 0.014

MYCN = 0 0.001


Log-rank test statistics (Mantel-Cox) are given (multiple testing correction by Benjamini-Hochberg) for comparison between the ultra-high risk group (HR-DOD) versus the low risk group (LR-SURV), and between the ultra-high risk group (HR-DOD) and all survivors (LR-SURV and HR-SURV). If a significant association (P < 0.05) was found in a particular stratum (associated with risk factors), this stratum is shown (multiple testing correction for the different comparisons by Benjamini-Hochberg). MYCN = 0: MYCN single copy ; EFS, event-free survival; OS, overall survival. P-values in bold indicate significant associations.

Decock et al. Genome Biology 2012 13:R95   doi:10.1186/gb-2012-13-10-r95

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