Table 1

Description of DNA methylation data sets

Set

Analysis

n

Tissue

Description

Mean age

Age range

Platform

Reference

Public availability


1

Consensus

92

WB

Dutch controls from ALS study

64

34-88

Infin 27 k

Novel data

GSE41037

2

Consensus

273

WB

Dutch controls from SZ study

33

16-65

Infin 27 k

Novel data

GSE41037

3

Consensus

293

WB

Dutch cases, SZ

34

17-86

Infin 27 k

Novel data

GSE41037

4

Consensus

190

WB

Type 1 diabetics

44

24-74

Infin 27 k

[15]

GSE20067

5

Consensus

87

WB

Healthy older women

63

49-74

Infin 27 k

[14]

GSE20236

6

Consensus

261

WB

Healthy postmenopausal women from UKOPS

65

52-78

Infin 27 k

[15,33]

GSE19711

7

Consensus

132

FCTX

FCTX brain

48

16-101

Infin 27 k

[18]

GSE15745

8

Consensus

126

TCTX

TCTX brain

48

15-101

Infin 27 k

[18]

GSE15745

9

Consensus

123

PONS

PONS brain

46

15-101

Infin 27 k

[18]

GSE15745

10

Consensus

111

CRBLM

CRBLM brain

47

16-96

Infin 27 k

[18]

GSE15745

11

Validation

94

WB 450 k

Controls and SZ

32

18-65

Illumina 450 k

Novel data

GSE41169

12

Validation

24

MSCs

MSCs

50

21-85

Infin 27 k

[34,35]

GSE26519+GSE17448

13

Validation

50

CD14+CD4+

CD4+ T-cells and CD14+ monocytes

36

16-69

Infin 27 k

[14]

GSE20242

14

Validation

398

Leukocyte

Pediatric population

10

3-17

Infin 27 k

[24]

GSE27097

15

Validation

72

Leukocyte

Healthy children

5

1-16

Illumina 450 k

[24]

GSE36064

16

Validation

108

Prefrontal cortex

Healthy controls

26

-0.5-84

Infin 27 k

[19]

BrainCloudMethyl


Data sets 1 to 10 were used in the consensus network analysis while data sets 11 to 16 were used in the module validation (preservation) analysis. Our novel WB DNA methylation data sets (numbered 1 to 3 and 11) are composed of (n = 92 + 273 + 293 + 94) individuals. The study involved multiple tissues (blood, brain) and different populations (adults and healthy children). Note that the mean age (and age ranges) differ greatly across the studies. ALS, amyotrophic lateral sclerosis; CRBLM, cerebellum; FCTX, frontal cortex; MSC, mesenchymal stromal cell; PONS, caudal pons; SZ, schizophrenia; TCTX, temporal cortex; UKOPS, United Kingdom Ovarian Cancer Population Study; WB, whole blood.

Horvath et al. Genome Biology 2012 13:R97   doi:10.1186/gb-2012-13-10-r97

Open Data