Association with matched non-tumor telomeric DNA content and age. (a) Comparison of age distribution of pediatric PCGP samples and adult TCGA samples. Because of the narrow range of age distribution in pediatric cancer in PCGP (n = 235, median = 7.5) we included 13 samples from TCGA (n = 13, median = 56) to enable evaluation of association between telomere length with age. (b) Comparison of distribution of normalized telomere count in matched normal DNA of pediatric patients with that of the adult patients. The reduction of telomere reads in adult is statistically significant (Wilcoxon signed rank P = 0.00046).
Parker et al. Genome Biology 2012 13:R113 doi:10.1186/gb-2012-13-12-r113