Research
Whole-genome reconstruction and mutational signatures in gastric cancer
- † Equal contributors
1 Computational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore
2 Genome Technology and Biology, Genome Institute of Singapore, Singapore 138672, Singapore
3 Cellular and Molecular Research, National Cancer Centre, Singapore 169610, Singapore
4 Cancer and Stem Cell Biology Program, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore 169857, Singapore
5 Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Singapore
6 Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore 169857, Singapore
7 NUS Graduate School of Integrative Sciences and Engineering, Centre for Life Sciences, Singapore 117456, Singapore
8 Research Computing, Genome Institute of Singapore, Singapore 138672, Singapore
9 NCCS-VARI Translational Research Laboratory, National Cancer Centre, Singapore 169610, Singapore
10 Genomic Oncology, Duke-NUS Graduate Medical School, Singapore 169857, Singapore
11 National Institute of Biomedical Genomics, 2nd Floor Netaji Subash Sanatorium, Kalyani 741251 West Bengal, India
12 Infectious Diseases, Genome Institute of Singapore, Singapore 138672, Singapore
13 Department of Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore
14 Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Singapore
15 Department of Pathology, National University Health System, National University of Singapore, Singapore 119074, Singapore
16 Department of Medicine, National University Health System, National University of Singapore, Singapore 119074, Singapore
17 Department of Surgery, National University Health System, National University of Singapore, Singapore 119074, Singapore
18 Department of Human Genetics, McGill University, Montréal H3A 1B, Canada
19 McGill University and Genome Quebec Innovation Center, Montréal H3A 1A4, Canada
20 Department of Biochemistry, National University of Singapore, Singapore 119074, Singapore
Genome Biology 2012, 13:R115 doi:10.1186/gb-2012-13-12-r115
Published: 13 December 2012Additional files
Additional file 1:
Supplementary Methods, Tables and Figures.
Format: DOCX Size: 2.7MB Download file
Additional file 2:
Table S6. Details of somatic SVs identified by DNA-PET in gastric tumors NGCII082 and NGCII092.
Format: XLS Size: 199KB Download file
This file can be viewed with: Microsoft Excel Viewer
Additional file 6:
Table S14. Enriched bases and motifs in the neighbourhood of C > A mutations.
Format: XLS Size: 33KB Download file
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Additional file 3:
Table S9. Genes recurrently mutated by non-synonymous SNVs or indels in four or more patients out of 40 GC exomes.
Format: XLS Size: 112KB Download file
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Additional file 4:
Table S10. Enriched functions and pathways in Gastric Cancer.
Format: XLS Size: 35KB Download file
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Additional file 5:
Table S12. Screen for recurrent mutations in 94 GC tumor/normal pairs by Sanger sequencing.
Format: XLS Size: 44KB Download file
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