Ontology profiling with colored de Bruijn graphs. Gene ontology profiles were obtained by coloring of the graph resulting from de novo assembly. Gene ontology has three domains: biological process, cellular component and molecular function. For each domain, only the 15 most abundant terms are displayed. (A) Ontology terms in the biological process domain were profiled. Some of these have several outlier samples, namely oxidation-reduction process and DNA recombination. (B) Ontology profiling for cellular component terms is shown. The most abundant is the membrane term. (C) The profile for molecular function terms is shown. Binding functions are the most abundant with ATP binding, nucleotide binding and DNA binding in the top three. Next is catalytic activity, which is a general term. More specific catalytic activities are listed.
Boisvert et al. Genome Biology 2012 13:R122 doi:10.1186/gb-2012-13-12-r122