False discovery rate and reproducibility of the dS score. (a) Plot of the false discovery rate of the dS score as a function of score magnitude. (b,c) Scatter of differential scores calculated on independent replicate subsets using (b) the B scores and (c) the dS score; the points shown in either panel are only those scored by both analyses. (d) Plot comparing the Pearson correlation of significant interactions for the B and dS scores (blue and green, respectively) over a full range of significance thresholds - that is, the correlation of the top n percent of the interactions for n = 0.1% (left side) to n = 100% (right side); error bars (non-bolded lines) indicate the 95% confidence intervals of the correlation coefficient.
Bean and Ideker Genome Biology 2012 13:R123 doi:10.1186/gb-2012-13-12-r123