Additional file 20.

DriverNet performance benchmarking on GBM, TN, HGS, and METABRIC datasets when copy number amplifications (AMP) and hemizygous deletions (HETDs) were included in addition to the high-level amplifications (HLAMP) and homozygous deletions (HOMDs). (A-D) Concordance with Cancer Gene Census for DriverNet, Frequency-based, and Fisher-based approaches as a function of the top N ranked genes (out of 200) for the GBM, TN, HGS, and METABRIC datasets, respectively. (E-H) Concordance with COSMIC database (cumulative distribution of mutation prevalence in the COSMIC database) for DriverNet, Frequency-based, and Fisher-based approaches as a function of the top N ranked genes (out of 200) for the GBM, TN, HGS, and METABRIC datasets, respectively.

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Bashashati et al. Genome Biology 2012 13:R124   doi:10.1186/gb-2012-13-12-r124