Table 2

The predicted rare drivers

Dataset

Gene

Gband

SNV/Indel

HLAMP

HOMD

Corrected P value

Percent altered


METABRIC

PTEN

10q23.31

0

0

16

0

1.54

METABRIC

RB1

13q14.2

0

0

16

0

1.54

METABRIC

MDM2

12q15

0

11

0

0

1.06

METABRIC

MYC

8q24.21

0

10

0

0

0.96

METABRIC

CDKN2A

9p21.3

0

0

16

0

1.54

METABRIC

CLTC

17q23.1

0

16

0

0

1.54

METABRIC

CREBBP

16p13.3

0

1

2

0

0.29

METABRIC

GNAS

20q13.32

0

7

0

0

0.67

METABRIC

EGFR

7p11.2

0

3

1

0

0.39

METABRIC

CDH1

16q22.1

0

0

16

0

1.54

METABRIC

CCNE1

19q12

0

6

1

0

0.67

METABRIC

EP300

22q13.2

0

0

4

0

0.39

METABRIC

CBL

11q23.3

0

0

13

0

1.25

METABRIC

PIK3R1

5q13.1

0

0

2

1.00E-04

0.19

METABRIC

JAK2

9p24.1

0

0

7

1.00E-04

0.67

METABRIC

TP53

17p13.1

0

0

7

2.00E-04

0.67

METABRIC

NUP98

11p15.4

0

0

8

0.0011

0.77

METABRIC

ATM

11q22.3

0

0

15

0.0149

1.45

METABRIC

PIK3CA

3q26.32

0

2

0

0.017

0.19

METABRIC

IDH2

15q26.1

0

4

1

0.017

0.48

METABRIC

KRAS

12p12.1

0

3

1

0.0348

0.39

METABRIC

TRA@

14q11.2

0

1

5

0.0388

0.58


TN

JAK1

1p31.3

1

0

0

0.0026

1.5


HGS

AKT2

19q13.2

0

3

1

0

1.32

HGS

KIT

4q12

5

0

1

2.00E-04

1.97

HGS

NRAS

1p13.2

2

0

0

9.00E-04

0.66

HGS

RPN1

3q21.3

2

0

0

0.0019

0.66

HGS

PIK3CA

3q26.32

2

0

0

0.0029

0.66

HGS

CREBBP

16p13.3

5

0

1

0.0031

1.97

HGS

PPP2R1A

19q13.33

3

0

1

0.0046

1.32

HGS

ATIC

2q35

2

0

1

0.005

0.99

HGS

CLTCL1

22q11.21

4

0

1

0.0068

1.64

HGS

MET

7q31.2

4

0

0

0.0132

1.32

HGS

MAP2K4

17p12

1

0

2

0.044

0.99

HGS

ETV1

7p21.2

1

1

1

0.0468

0.99

HGS

EP300

22q13.2

1

0

3

0.0492

1.32


GBM

KRAS

12p12.1

1

0

1

1.41

1.67

GBM

AKT1

14q32.33

0

1

0

1.64

0.83


Bashashati et al. Genome Biology 2012 13:R124   doi:10.1186/gb-2012-13-12-r124

Open Data