Table 2 |
|||||||
|
The predicted rare drivers |
|||||||
|
Dataset |
Gene |
Gband |
SNV/Indel |
HLAMP |
HOMD |
Corrected P value |
Percent altered |
|
|
|||||||
|
METABRIC |
PTEN |
10q23.31 |
0 |
0 |
16 |
0 |
1.54 |
|
METABRIC |
RB1 |
13q14.2 |
0 |
0 |
16 |
0 |
1.54 |
|
METABRIC |
MDM2 |
12q15 |
0 |
11 |
0 |
0 |
1.06 |
|
METABRIC |
MYC |
8q24.21 |
0 |
10 |
0 |
0 |
0.96 |
|
METABRIC |
CDKN2A |
9p21.3 |
0 |
0 |
16 |
0 |
1.54 |
|
METABRIC |
CLTC |
17q23.1 |
0 |
16 |
0 |
0 |
1.54 |
|
METABRIC |
CREBBP |
16p13.3 |
0 |
1 |
2 |
0 |
0.29 |
|
METABRIC |
GNAS |
20q13.32 |
0 |
7 |
0 |
0 |
0.67 |
|
METABRIC |
EGFR |
7p11.2 |
0 |
3 |
1 |
0 |
0.39 |
|
METABRIC |
CDH1 |
16q22.1 |
0 |
0 |
16 |
0 |
1.54 |
|
METABRIC |
CCNE1 |
19q12 |
0 |
6 |
1 |
0 |
0.67 |
|
METABRIC |
EP300 |
22q13.2 |
0 |
0 |
4 |
0 |
0.39 |
|
METABRIC |
CBL |
11q23.3 |
0 |
0 |
13 |
0 |
1.25 |
|
METABRIC |
PIK3R1 |
5q13.1 |
0 |
0 |
2 |
1.00E-04 |
0.19 |
|
METABRIC |
JAK2 |
9p24.1 |
0 |
0 |
7 |
1.00E-04 |
0.67 |
|
METABRIC |
TP53 |
17p13.1 |
0 |
0 |
7 |
2.00E-04 |
0.67 |
|
METABRIC |
NUP98 |
11p15.4 |
0 |
0 |
8 |
0.0011 |
0.77 |
|
METABRIC |
ATM |
11q22.3 |
0 |
0 |
15 |
0.0149 |
1.45 |
|
METABRIC |
PIK3CA |
3q26.32 |
0 |
2 |
0 |
0.017 |
0.19 |
|
METABRIC |
IDH2 |
15q26.1 |
0 |
4 |
1 |
0.017 |
0.48 |
|
METABRIC |
KRAS |
12p12.1 |
0 |
3 |
1 |
0.0348 |
0.39 |
|
METABRIC |
TRA@ |
14q11.2 |
0 |
1 |
5 |
0.0388 |
0.58 |
|
|
|||||||
|
TN |
JAK1 |
1p31.3 |
1 |
0 |
0 |
0.0026 |
1.5 |
|
|
|||||||
|
HGS |
AKT2 |
19q13.2 |
0 |
3 |
1 |
0 |
1.32 |
|
HGS |
KIT |
4q12 |
5 |
0 |
1 |
2.00E-04 |
1.97 |
|
HGS |
NRAS |
1p13.2 |
2 |
0 |
0 |
9.00E-04 |
0.66 |
|
HGS |
RPN1 |
3q21.3 |
2 |
0 |
0 |
0.0019 |
0.66 |
|
HGS |
PIK3CA |
3q26.32 |
2 |
0 |
0 |
0.0029 |
0.66 |
|
HGS |
CREBBP |
16p13.3 |
5 |
0 |
1 |
0.0031 |
1.97 |
|
HGS |
PPP2R1A |
19q13.33 |
3 |
0 |
1 |
0.0046 |
1.32 |
|
HGS |
ATIC |
2q35 |
2 |
0 |
1 |
0.005 |
0.99 |
|
HGS |
CLTCL1 |
22q11.21 |
4 |
0 |
1 |
0.0068 |
1.64 |
|
HGS |
MET |
7q31.2 |
4 |
0 |
0 |
0.0132 |
1.32 |
|
HGS |
MAP2K4 |
17p12 |
1 |
0 |
2 |
0.044 |
0.99 |
|
HGS |
ETV1 |
7p21.2 |
1 |
1 |
1 |
0.0468 |
0.99 |
|
HGS |
EP300 |
22q13.2 |
1 |
0 |
3 |
0.0492 |
1.32 |
|
|
|||||||
|
GBM |
KRAS |
12p12.1 |
1 |
0 |
1 |
1.41 |
1.67 |
|
GBM |
AKT1 |
14q32.33 |
0 |
1 |
0 |
1.64 |
0.83 |
|
|
|||||||
|
Bashashati et al. Genome Biology 2012 13:R124 doi:10.1186/gb-2012-13-12-r124 |
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