Open Access Method

RIDDLE: reflective diffusion and local extension reveal functional associations for unannotated gene sets via proximity in a gene network

Peggy I Wang12, Sohyun Hwang3, Rodney P Kincaid24, Christopher S Sullivan24, Insuk Lee3* and Edward M Marcotte25*

Author Affiliations

1 Department of Biomedical Engineering, The University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA

2 Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA

3 Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-749, Korea

4 Molecular Genetics and Microbiology, College of Natural Sciences, University of Texas at Austin, 2506 Speedway, Austin, TX 78712, USA

5 Department of Chemistry and Biochemistry, University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA

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Genome Biology 2012, 13:R125  doi:10.1186/gb-2012-13-12-r125

Published: 26 December 2012

Additional files

Additional file 1:

Supplementary Figures S1 to S7 and Table S1.

Format: DOCX Size: 2MB Download file

Open Data

Additional file 2:

Supplementary Table S2. Results produced using RIDDLE to match predicted targets of miR-450a with OMIM disease genes.

Format: XLSX Size: 143KB Download file

Open Data