Reflective diffusion (RD) operates on the principal that a seed set predicts a terminal set if the terminal genes are ranked highly by network diffusion score. Recovery is measured by area under the ROC curve (AUC) or average precision (AP). Higher scores for both measures indicate stronger functional association.
Wang et al. Genome Biology 2012 13:R125 doi:10.1186/gb-2012-13-12-r125