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The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks

Tatiana V Morozova12, David Goldman3, Trudy FC Mackay24 and Robert RH Anholt124*

Author Affiliations

1 Department of Biology, Box 7617, North Carolina State University, Raleigh, NC 27695, USA

2 WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA

3 National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA

4 Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA

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Genome Biology 2012, 13:239 doi:10.1186/gb-2012-13-2-239

Published: 20 February 2012

Abstract

Alcoholism is a significant public health problem. A picture of the genetic architecture underlying alcohol-related phenotypes is emerging from genome-wide association studies and work on genetically tractable model organisms.

Keywords:
Addiction; alcohol sensitivity; disease susceptibility; genome-wide association studies; human genetics; model organisms