Open Access Research

Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase

Radek Szklarczyk1*†, Bas FJ Wanschers1,2†, Thomas D Cuypers1,3, John J Esseling4, Moniek Riemersma2, Mariël AM van den Brand2, Jolein Gloerich5, Edwin Lasonder1, Lambert P van den Heuvel2, Leo G Nijtmans2 and Martijn A Huynen1*

1 Centre for Molecular and Biomolecular Informatics, Radboud University Nijmegen Medical Centre, Nijmegen, 6500 HB, The Netherlands

2 Nijmegen Centre for Mitochondrial Disorders at the Department of Pediatrics, Radboud University Nijmegen Medical Centre, Nijmegen, 6500 HB, The Netherlands

3 Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, 3584 CH, The Netherlands

4 Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, 6500 HB, The Netherlands

5 Nijmegen Proteomics Facility, Department of Laboratory Medicine, Laboratory of Genetic, Endocrine and Metabolic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, 6500 HB, The Netherlands

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Genome Biology 2012, 13:R12 doi:10.1186/gb-2012-13-2-r12

Published: 22 February 2012

Additional files

Additional file 1:

Additional Table S6 - human orthologs of fungal mitochondrial proteins.

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Additional file 2:

Additional Text, Tables S1 to S5 and S7 to S9 and Figures S1 to S4.

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