Hierarchical clustering of the M value and motif scores in all H3K27ac peaks of H1 ES cells and K562 cells. (a,b) Hierarchical clustering was applied to the correlation coefficients of M values (= log2 (Read density in H1 ES/Read density in K562)) or -M values (= log2 (Read density in K562/Read density in H1 ES)) of all H3K27ac peaks identified in H1 ES cells (a) or K562 cells (b), with motif scores determined for 130 JASPAR vertebrate core motifs in the peak regions. Only the motifs significantly enriched in the peaks of either cell type are shown here (enrichment score > 1.2 and Bonferroni corrected P-value < 1e-5 by Fisher exact test). The names of the motifs closely clustered with M value or -M value are colored in red.
Shao et al. Genome Biology 2012 13:R16 doi:10.1186/gb-2012-13-3-r16