Table 4

Haploinsufficient loci with developmental or cellular phenotypes not associated with strong haplolethality or haplosterility

Gene

Location

Phenotype

Referencea


N

3C7-9

Wing notching

[47]

Hupb

7BC

Pronotal outgrowth

[48]

run

19E2

Segmentation defects

[49]

S

21E4

Eye roughness

[50]

Pkd2

33E3

Reduced smooth muscle contractility

[51]

b

34D1

Darker body color

[52]

Mhc

36B1

Muscle defects

[53]

lok

38B2

No apoptosis after telomere loss

[54]

vg

49E1

Wing notching

[55]

Np/CG34350c

45A1

Notopleural bristle length

[56]

Pcl

55B8

2nd to 1st leg transformation

[57]

bsd

60C6

Wing venation defects

[58]

Dll

60E2

Antenna to leg transformation

[59]

Kr

60F5

Segmentation defects

[60]

mtrm

66C11

Increased female nondisjunction

[61]

Pc

78C6-7

2nd to 1st leg transformation

[62]

Scr

84A5

1st to 2nd leg transformation

[63]

Tm2

88E13

Muscle defects

[64]

Act88F

88F5

Muscle defects

[65]

Ubx

89D9

Haltere to wing transformation

[66]

Dl

92A1-2

Wing venation defects

[67]

bnl

92B2-3

Abnormal tracheal branching

[68]

H

92F3

Bristle shaft to socket transformation

[33]

e

93C7-D1

Darker body color

[48]

p53

94D10

No apoptosis after telomere loss

[54]

Mlc2

99E1

Muscle defects

[69]


aReference originally describing haploinsufficiency. bHumeral patch (Hup) is the only locus in this list not mapped to a specific transcription unit. cAllelism of Notopleural (Np) and CG34350 demonstrated by Laurence von Kalm (personal communication). dPlexate (Px) is a haploinsufficient locus closely linked or allelic to blistered (bs) with similar phenotypes. We have assumed allelism.

Cook et al. Genome Biology 2012 13:R21   doi:10.1186/gb-2012-13-3-r21

Open Data