Figure 4.

Simulated Venter chromosome 17. ROC curves comparing deletion predictions for Breakdancer, GASV, GASVPro-HQ, Hydra-HQ, CNVer, GASVPro and Hydra to the 124 deletions from Venter chromosome 17 with minimum deletion length 125 bp. All methods analyzed the same set of high-quality unique mappings; in addition, GASVPro and Hydra considered a set of lower-quality alignments, including ambiguous fragments with multiple alignments. Predictions of all methods were post-processed in an identical fashion and the resulting predictions were compared to the known coordinates for the Venter deletions according to the double uncertainty metric (see Methods).

Sindi et al. Genome Biology 2012 13:R22   doi:10.1186/gb-2012-13-3-r22
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