Structural predictions of TF DNA binding domains. To date, we have created 212 structural predictions of the active sites of select TFs in TFe. We focused on TFs for which a structural prediction is most feasible and whose articles are nearing completion. These predictions were generated with an in-house, custom-made pipeline that finds the most similar, experimentally determined protein structure for each unsolved TF, and uses that experimentally determined 'template' to guide the prediction of the unknown structure.
Yusuf et al. Genome Biology 2012 13:R24 doi:10.1186/gb-2012-13-3-r24