Genetic architecture of body size in mammals
1 Faculty of Land and Environment, University of Melbourne, Parkville, Victoria 3010, Australia
2 University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
3 The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia
4 Victorian Department of Primary Industries, AgriBiosciences Centre, LaTrobe Research and Development Park, Bundoora, Victoria 3083, Australia
Genome Biology 2012, 13:244 doi:10.1186/gb-2012-13-4-244Published: 30 April 2012
Much of the heritability for human stature is caused by mutations of small-to-medium effect. This is because detrimental pleiotropy restricts large-effect mutations to very low frequencies.