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Highly Accessed Review

Genetic architecture of body size in mammals

Kathryn E Kemper1*, Peter M Visscher23 and Michael E Goddard14

Author affiliations

1 Faculty of Land and Environment, University of Melbourne, Parkville, Victoria 3010, Australia

2 University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia

3 The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia

4 Victorian Department of Primary Industries, AgriBiosciences Centre, LaTrobe Research and Development Park, Bundoora, Victoria 3083, Australia

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Citation and License

Genome Biology 2012, 13:244  doi:10.1186/gb-2012-13-4-244

Published: 30 April 2012

Abstract

Much of the heritability for human stature is caused by mutations of small-to-medium effect. This is because detrimental pleiotropy restricts large-effect mutations to very low frequencies.

Keywords:
Human height; mutation effects; mutation-selection balance