Open Access Research

Mediation of Drosophila autosomal dosage effects and compensation by network interactions

John H Malone12, Dong-Yeon Cho3, Nicolas R Mattiuzzo1, Carlo G Artieri14, Lichun Jiang15, Ryan K Dale1, Harold E Smith6, Jennifer McDaniel7, Sarah Munro7, Marc Salit7, Justen Andrews8, Teresa M Przytycka3* and Brian Oliver1*

Author Affiliations

1 Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, 50 South Drive, Bethesda, MD 20892, USA

2 Department of Biology, Florida State University, 319 Stadium Drive, Tallahassee, FL 32306, USA

3 Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20814, USA

4 Department of Biology, 385 Serra Mall, Stanford University, Stanford, CA 94304, USA

5 Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA

6 Genomics Core, National Institute of Diabetes and Digestive and Kidney Diseases, 8 Center Drive, Bethesda, MD 20814, USA

7 Biochemical Science Division, Molecular Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899, USA

8 Department of Biology, Indiana University, 1001 East 3rd Street, Bloomington, IN 47405, USA

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Genome Biology 2012, 13:R28  doi:10.1186/gb-2012-13-4-r28

Published: 24 April 2012

Additional files

Additional file 1:

Figure. DNA-seq of Df/+ lines.

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Additional file 2:

Expression of one-dose genes (Excel).

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Additional file 3:

Compensation by position along chromosome arm 2L.

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Additional file 4:

Expression of two-dose genes (Excel).

Format: XLS Size: 748KB Download file

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Additional file 5:

Female mutual information network (Cytoscape).

Format: CYS Size: 6.4MB Download file

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Additional file 6:

Male mutual information network (Cytoscape).

Format: CYS Size: 4.5MB Download file

Open Data