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Enhancer dysfunction: how the main regulators of gene expression contribute to cancer

Siavash K Kurdistani

Author Affiliations

Department of Biological Chemistry and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA

Genome Biology 2012, 13:156  doi:10.1186/gb-2012-13-5-156

Published: 23 May 2012

Abstract

A genome-wide epigenetic analysis of enhancer elements in colon cancer has implicated distal gene regulatory DNA sequences in the establishment of an oncogenic transcriptional program.