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High-throughput sequencing to decipher the genetic heterogeneity of deafness

Zippora Brownstein, Yoni Bhonker and Karen B Avraham*

Author Affiliations

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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Genome Biology 2012, 13:245 doi:10.1186/gb-2012-13-5-245

Published: 29 May 2012

Abstract

Identifying genes causing non-syndromic hearing loss has been challenging using traditional approaches. We describe the impact that high-throughput sequencing approaches are having in discovery of genes related to hearing loss and the implications for clinical diagnosis.

Keywords:
Genomics; deep sequencing; massive parallel sequencing; next-generation sequencing; exome sequencing; homozygosity mapping; hearing loss