Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

Highly Accessed Review

High-throughput sequencing to decipher the genetic heterogeneity of deafness

Zippora Brownstein, Yoni Bhonker and Karen B Avraham*

Author Affiliations

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

For all author emails, please log on.

Genome Biology 2012, 13:245  doi:10.1186/gb-2012-13-5-245

Published: 29 May 2012

Abstract

Identifying genes causing non-syndromic hearing loss has been challenging using traditional approaches. We describe the impact that high-throughput sequencing approaches are having in discovery of genes related to hearing loss and the implications for clinical diagnosis.

Keywords:
Genomics; deep sequencing; massive parallel sequencing; next-generation sequencing; exome sequencing; homozygosity mapping; hearing loss