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A new approach for detecting low-level mutations in next-generation sequence data

Mingkun Li* and Mark Stoneking

Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D04103, Leipzig, Germany

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Genome Biology 2012, 13:R34 doi:10.1186/gb-2012-13-5-r34

Published: 23 May 2012

Additional files

Additional file 1:

Supplemental figures. This file contains Figures S1, S2, S3, S4, S5, S6, S7, and S8.

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Additional file 2:

Supplemental materials and methods. Supplemental materials and methods include the following sections: Calculation of bias assuming a Poisson distribution; Calculation of bias using the Fisher exact test; Calculation of bias using the empirical distribution; Refinement of the method.

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Additional file 3:

Supplemental tables. This file contains Tables S1, S2, S3, S5, and S6.

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Additional file 4:

Table S4 - LLMs detected in the mtDNA dataset. An EXCEL table listing all the LLMs detected in the mtDNA dataset.

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