Additional file 2.

Supplemental materials and methods. Supplemental materials and methods include the following sections: Calculation of bias assuming a Poisson distribution; Calculation of bias using the Fisher exact test; Calculation of bias using the empirical distribution; Refinement of the method.

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Li and Stoneking Genome Biology 2012 13:R34   doi:10.1186/gb-2012-13-5-r34