Figure 5.

Proposed explanations for the observed and predicted phenotypes of E. coli B strains derived from the combined analysis of genome, transcriptome, and proteome data. In the inner circle, observations from this study are marked with a green background and hypotheses generated in this study are shown in pink. Genes with elevated mRNA or protein expression in B (red circle) or K-12 (green circle) strains are shown. Genetic differences between B and K-12 strains are denoted as follows: Δ, absence in B; -, pseudogene in B. Red arrows denote the phenotypes and related genetic backgrounds supported by flux balance analysis using the reconstructed metabolic model of the B strain.