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Deciphering membrane protein structures from protein sequences

Tilman Flock*†, AJ Venkatakrishnan†, KR Vinothkumar and M Madan Babu*

Author Affiliations

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK

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Genome Biology 2012, 13:160 doi:10.1186/gb-2012-13-6-160

Published: 27 June 2012

Abstract

Co-evolving positions within protein sequences have been used as spatial constraints to develop a computational approach for modeling membrane protein structures.

Keywords:
Co-evolution; membrane proteins; mutual information; protein sequence; structure