Figure 2.

Mutational changes in the genomes of 48 evolved isolates from slow- and fast-dilution rate populations. (a) Genome changes in the 0.1 h^-1 populations. The thin circle shows the map of the ancestor genome with the genes altered in isolates. The populations that the isolates came from are color-coded: population 1 (blue), population 2 (green), population 3 (orange) and population 4 (grey). The outer three circles show the mutations in the three mutator isolates BW4004, BW4040 and W3767 (outermost to innermost) and the other circles represent the following isolates in order towards the center: 3X37, BW4030, BW4002, 4R1, 3X30, 3X27, 2W14, 4R23, 4R17, 4R16, 3X16, 3X10, 2W29, 2W22, BW4005, 4R10, 3X31, 3X17, 2W30, 2W11, 2W2, BW4029, 4R18, BW4001. The mutations are also color-coded, so identical mutations in the same gene share the same color. (b) Genome changes in 0.6 h^-1 populations. The thin circle shows the map of the ancestor genome with the genes altered in isolates. The populations that the isolates came from are color-coded: population 5 (orange), population 8 (green), population 10 (blue) and population 11 (grey). The outer circle shows the mutations in the mutator isolate 10W34 and the other circles represent the following isolates in order towards the center: 10W40, 8W33, 10W21, 5W3, 8W21, 5W30, 5W19, 11Za3, 5W21, 11Za12, 8W20, 11Za16, 11Za1, 8W18, 5W23, 11Za5, 11Za4, 8W37, 8W17 and 5W25. The mutations are also color-coded, so identical mutations in the same gene share the same color.