Figure 6.

Functional changes in 85 mutations identified in 44 non-mutator isolates from 4 slow-growing cultures and 4 fast growing cultures. Groupings of genes were based on COGs (Clusters of Orthologous Groups) [74]. COG codes: D, cell cycle control and mitosis; E, amino acid metabolism and transport; G, carbohydrate metabolism and transport; K, transcription; L, replication and repair; M, cell wall/membrane/envelope biogenesis; N, cell motility; O, post-translational modification, protein turnover, chaperone functions; S, function unknown; T, signal transduction; V, intracellular trafficking and secretion; N.A., not analyzed.