Figure 4.

Weighted gene co-methylation network analysis of DNA methylation at intragenic CGIs. (a) Dendrograms produced by average linkage hierarchical clustering of intragenic CGIs on the basis of topological overlap. Modules of co-methylated loci were assigned colors as indicated by the horizontal bar beneath each dendrogram. The 'blue' module was strongly negatively co-methylated (r² = -0.98, P = 4 × 10^-5) in cortex. (b) IPA on the genes associated with the blue module highlighted a network involved in nervous system development and function.