DNA methylation across LCPs is strongly associated with tissue type. (a) MEDIPS scores across both HCPs and LCPs can be used to accurately cluster samples by tissue type, but the strength of clustering, indicated by Pearson dissimilarity on the y-axis, is much higher in LCPs. (b, c) This pattern is reflected in three-factor PCA plots (b) and correlation analyses (c), with LCPs demonstrating stronger tissue-specific patterns of DNA methylation than HCPs.
Davies et al. Genome Biology 2012 13:R43 doi:10.1186/gb-2012-13-6-r43