Figure 6.

Gene Ontology and pathway analysis of G₀ TFs.Quiescence genes with differential expression in G₀ TF knockout microarrays were studied with ranked enrichment analysis in g:Profiler. Statistically significant non-redundant functional Gene Ontology categories are shown (hypergeometric test, FDR p ≤ 0.05). Black bars correspond to total number of G₀ genes in a given category, and coloured bars show the number of times these genes were up-regulated (red) or down-regulated (green) in related G₀ ΔTFs, according to knockout data. Enrichment p-value is shown in vertical colour strips on the left. Top: functional enrichments of quiescence genes associated to all G₀ TFs; middle: functional enrichments specific to TFs with reduced viability phenotype; bottom: Functional enrichments specific to WT+ TFs with increased viability phenotype. GO, Gene Ontology; TF, transcription factor.