Table 1

Overview of protein domains that are enriched among proteins not previously known to bind RNA

Putative non-classical RNA-binding domain

Identified in study led by:

Domain previously described to bind RNA

Hentze [2]

Landthaler [3]

AlbA-like DNA binding

✔

Yes

CBF

✔

No

DZF

✔

No

FAST and RAP

✔

✔*

No

HAT helix

✔

No

HMG box

✔^¶

✔

Yes

MMR HSR1

✔

No

PAP associated

✔

✔*

No

polyK-patches

✔

No

SAP

✔

✔

Yes

SWAP/SURP

✔

Yes

WD40

✔

Yes

'Winged helix' DNA binding

✔

No

YGG boxes

✔

No

ZNF motif

Subtype AKAP95

✔

✔*

No

Subtype HC5HC2H

✔

No

*Corrected P-value >0.05; ^¶P-value >0.1.

Sibley et al. Genome Biology 2012 13:163   doi:10.1186/gb-2012-13-7-163