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piRNAs and siRNAs collaborate in Caenorhabditis elegans genome defense

Allison C Billi12, Mallory A Freeberg13 and John K Kim12*

Author Affiliations

1 Life Sciences Institute, Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-2216, USA

2 Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-2216, USA

3 Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109-2216, USA

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Genome Biology 2012, 13:164  doi:10.1186/gb-2012-13-7-164

Published: 20 July 2012

Abstract

Caenorhabditis elegans piRNAs promote genome surveillance by triggering siRNA-mediated silencing of nonself DNA in competition with licensing programs that support endogenous gene expression.

Keywords:
piRNA; siRNA; Piwi; C. elegans; germline; genome surveillance; epigenetics; gene silencing; transposable elements