Research highlight
piRNAs and siRNAs collaborate in Caenorhabditis elegans genome defense
1 Life Sciences Institute, Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-2216, USA
2 Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-2216, USA
3 Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109-2216, USA
Genome Biology 2012, 13:164 doi:10.1186/gb-2012-13-7-164
Published: 20 July 2012Abstract
Caenorhabditis elegans piRNAs promote genome surveillance by triggering siRNA-mediated silencing of nonself DNA in competition with licensing programs that support endogenous gene expression.
