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The aging epigenome: DNA methylation from the cradle to the grave

Marc Winnefeld1 and Frank Lyko2*

Author Affiliations

1 Research and Development, Beiersdorf AG, Hamburg, Germany

2 Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany

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Genome Biology 2012, 13:165  doi:10.1186/gb-2012-13-7-165

Published: 30 July 2012

Abstract

Whole-genome methylation analysis of newborns and centenarians reveals widespread epigenetic alterations, and provides new insight into age-related methylation pattern changes.