Table 1

Pearson correlations between features and negative genetic interaction degree in S. pombe (pom) and S. cerevisiae (cer) are observed to be significant in many cases

Pearson's r

P-value

95% CI

SM fitness defect

pom

0.48

9.90E-31

[0.41, 0.54]

cer

0.75

0.00E+00

[0.77, 0.74]

Multifunctionality

pom

0.3

1.01E-12

[0.22, 0.37]

cer

0.26

4.52E-53

[0.29, 0.23]

Conservation

pom

0.07

1.06E-01

[-0.01, 0.15]

cer

0.16

7.11E-21

[0.19, 0.13]

Broad conservation

pom

0

9.30E-01

[-0.09, 0.08]

cer

0.16

9.90E-19

[0.19, 0.12]

PPI degree

pom

0.2

5.84E-03

[0.06, 0.33]

cer

0.15

1.49E-19

[0.19, 0.12]

Expression level

pom

-0.05

2.42E-01

[-0.13, 0.03]

cer

0.11

7.40E-10

[0.14, 0.08]

Disorder

pom

0.13

3.05E-03

[0.04, 0.21]

cer

0.11

1.91E-10

[0.14, 0.08]

Codon Adaptation Index

pom

-0.02

6.49E-01

[-0.1, 0.06]

cer

0.09

1.91E-07

[0.12, 0.06]

Protein length

pom

0

9.18E-01

[-0.08, 0.09]

cer

0.05

3.57E-03

[0.08, 0.02]

Co-expression degree

pom

0

9.38E-01

[-0.08, 0.09]

cer

0.05

3.75E-03

[0.08, 0.02]

Number of domains

pom

-0.01

7.37E-01

[-0.1, 0.07]

cer

0.01

4.54E-01

[0.05, -0.02]

Number of unique domains

pom

-0.02

6.86E-01

[-0.1, 0.07]

cer

0.01

6.98E-01

[0.04, -0.03]

Nc

pom

-0.01

7.56E-01

[-0.1, 0.07]

cer

-0.08

2.95E-06

[-0.05, -0.11]

dN/dS

pom

-0.05

2.48E-01

[-0.14, 0.04]

cer

-0.11

1.58E-09

[-0.07, -0.14]

Copy number

pom

-0.08

5.26E-02

[-0.17, 0]

cer

-0.12

1.01E-11

[-0.08, -0.15]

Expression variation

pom

-0.15

4.11E-04

[-0.23, -0.07]

cer

-0.18

3.87E-27

[-0.15, -0.21]

CI, confidence interval; PPI, protein-protein interaction; SM, single mutant

Koch et al. Genome Biology 2012 13:R57   doi:10.1186/gb-2012-13-7-r57