Figure 5.

Relationship between APA and transformation. (a) Proximal PUIs calculated for proliferating, RAS-transformed and confluent BJ cells. (b) Distribution of APA events induced by RAS transformation according to net effect on transcript 3' UTR length. (c) Proliferation index calculated for proliferating, RAS-transformed and confluent BJ cells. (d) Proximal PUIs calculated for proliferating, RAS-transformed (2 and 8 days after RAS^G12V induction) and serum-starved MCF10A cells. (e) Distribution of APA events that were consistently induced by RAS transformation at both 2 days and 8 days, according to net effect on transcript 3' UTR length. (f) Proliferation index calculated for proliferating, RAS-transformed and serum-starved MCF10A cells.