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CIDeR: multifactorial interaction networks in human diseases

Martin Lechner1, Veit Höhn1, Barbara Brauner1, Irmtraud Dunger1, Gisela Fobo1, Goar Frishman1, Corinna Montrone1, Gabi Kastenmüller1, Brigitte Waegele12 and Andreas Ruepp1*

Author Affiliations

1 Institute for Bioinformatics and Systems Biology (MIPS), Helmholtz Center Munich - German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany

2 Department of Genome-oriented Bioinformatics, Life and Food Science Center Weihenstephan, Technische Universität München, Alte Akademie 1, 85354 Freising, Germany

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Genome Biology 2012, 13:R62  doi:10.1186/gb-2012-13-7-r62

Published: 18 July 2012

Abstract

The pathobiology of common diseases is influenced by heterogeneous factors interacting in complex networks. CIDeR http://mips.helmholtz-muenchen.de/cider/ webcite is a publicly available, manually curated, integrative database of metabolic and neurological disorders. The resource provides structured information on 18,813 experimentally validated interactions between molecules, bioprocesses and environmental factors extracted from the scientific literature. Systematic annotation and interactive graphical representation of disease networks make CIDeR a versatile knowledge base for biologists, analysis of large-scale data and systems biology approaches.