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Staphylococcus epidermidis pan-genome sequence analysis reveals diversity of skin commensal and hospital infection-associated isolates

Sean Conlan1, Lilia A Mijares123, NISC Comparative Sequencing Program4, Jesse Becker4, Robert W Blakesley4, Gerard G Bouffard4, Shelise Brooks4, Holly Coleman4, Jyoti Gupta4, Natalie Gurson4, Morgan Park4, Brian Schmidt4, Pamela J Thomas4, Michael Otto5, Heidi H Kong6, Patrick R Murray2 and Julia A Segre1*

Author Affiliations

1 National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA

2 Department of Laboratory Medicine, NIH Clinical Center, NIH, Bethesda, MD 20892, USA

3 Department of Medical Research and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA

4 NIH Intramural Sequencing Center, NIH, Rockville, MD 20852, USA

5 Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA

6 Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA

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Genome Biology 2012, 13:R64  doi:10.1186/gb-2012-13-7-r64

Published: 25 July 2012

Additional files

Additional file 1:

Genome assembly metrics. The Contig N50 indicates that 50% of the bases are in contigs of this size or larger. Average coverage is the average number of reads contributing to a given position in the contig.

Format: XLS Size: 30KB Download file

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Additional file 2:

Strain metadata. Subject metadata are presented for each strain sequenced in this study. The age column indicates the age of the subject at the time of strain isolation. The subject race/ethnicity is indicated as white, black or hispanic. For nosocomial isolates, a condensed patient history is provided leading up to strain isolation.

Format: XLS Size: 70KB Download file

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Additional file 3:

Optical mapping of ST2 isolates NIH05001 and NIH05005. Optical maps were aligned and displayed with the MapSolver 3.1 software. Aligned regions are in blue. Insertions relative to a genome are in white. Inversions and duplications are in red.

Format: PNG Size: 70KB Download file

Open Data