Figure 3.

Relationship between promoter DNA methylation and embryonic gene expression. (a) Schematic representation of the developmental gene expression cohorts previously identified by RNA-seq [10] (numbers of genes encoding the corresponding transcripts). (b) Proportions of genes with a methylated promoter (-1/0 kb) in each cohort at the pre-MBT, MBT and post-MBT stages. *P < 10^-4 relative to RefSeq genes (Fisher). (c) Proportions of LCPs and HCPs in each gene cohort. *P < 10^-4 relative to RefSeq genes (Fisher).