Relationship between promoter DNA methylation and embryonic gene expression. (a) Schematic representation of the developmental gene expression cohorts previously identified by RNA-seq  (numbers of genes encoding the corresponding transcripts). (b) Proportions of genes with a methylated promoter (-1/0 kb) in each cohort at the pre-MBT, MBT and post-MBT stages. *P < 10-4 relative to RefSeq genes (Fisher). (c) Proportions of LCPs and HCPs in each gene cohort. *P < 10-4 relative to RefSeq genes (Fisher).
Andersen et al. Genome Biology 2012 13:R65 doi:10.1186/gb-2012-13-7-r65