Maternal genes are preferentially hypomethylated relative to zygotic or non-expressed genes. (a) Hypomethylated domain over the hoxa locus in embryos and ZF4 cells. (b) Venn diagram analysis of hypomethylated genes at pre-MBT, MBT and post-MBT stages. (c) Domains of high o/e CG ratios exhibit hypomethylation, exemplified in a 51-kb region of chromosome 11 in pre-MBT embryos. (d) Proportions of hypomethylated genes in developmental gene cohorts. a,b/a,c/b,cP < 10-4 within developmental stage (Fisher).
Andersen et al. Genome Biology 2012 13:R65 doi:10.1186/gb-2012-13-7-r65