Figure 5.

Enrichment of hypomethylated and methylated genes in, respectively, H3K4me3 and H3K9me3. (a) Post-MBT proportions of H3K4me3, H3K9me3 and H3K27me3 enrichment on methylated promoters, hypomethylated promoters and promoters with genome-average methylation (that is, neither statistically hypomethylated nor methylated; 'No Me'). *P < 10^-4 relative to the opposite methylation state (Fisher). Histone methylation data are from our laboratory [13]. (b) Proportions of hypomethylated promoters not marked by H3K4me3 (or any other histone modification), or co-enriched in H3K4me3 only or with a repressive mark (H3K9me3, or H3K27me3, or both).