Hypothetical categorization of low-iron-inducible cell surface proteins. In low-iron conditions we find an up-regulation of diverse genes, whose products are targeted to the secretory pathway, suggesting extensive cell surface remodeling. Many of these are predicted to be involved in adhesion or degradation processes and might contribute to enhancing the overall cellular capacity to bind and process external organic matter. We provide a hypothetical categorization for highly responsive genes that can be assigned to this function. While some of the gene products can be placed in the context of iron uptake (right), others are less well defined, but contain a variety of conserved domains involved in adhesion or degradation of organic matter (left). Especially for larger genes, EST support is patchy, suggesting possible inaccuracies in AUGUSTUS gene modeling. Differential read contribution from the Fe(-) and Fe(+) libraries to each transcript contig (ESTs) is taken as a measure for the differential transcription of the respective gene.
Lommer et al. Genome Biology 2012 13:R66 doi:10.1186/gb-2012-13-7-r66