Figure 3.

Quantification of PTMs on histone H3 and H4 peptides isolated with HP1 and Brd proteins. (a) Heatmap depicting all modified forms of H3 peptides on HP1- and Brd-bound nucleosomes by qMS. Values used to generate the heatmap are in Additional files 2 and 6. The heatmap was generated with the fold change values for each modified H3 peptide quantified from each specified ChIP/Input in (log₂) scale. (b) Heatmap depicting all modified forms of H4 peptides on HP1- and Brd-bound nucleosomes by mass spectrometry. Values used to generate the heatmap are in Additional files 2 and 3. The heatmap was generated with the fold change values for each modified H4 peptide quantified from each specified ChIP/Input in (log₂) scale.