Stem cell-like activity correlates with tumor grade in various solid malignancies. Each panel displays the distribution, within the space of the stem cell genes, of graded tumor samples for one particular tissue type. Our stemness index consistently separates high-grade tumors from low grade ones. Based on this transcriptional index, the mid-grade tumors are less well defined.
Palmer et al. Genome Biology 2012 13:R71 doi:10.1186/gb-2012-13-8-r71