Table 2

Enrichment of PANTHER ontology terms from a list of 394 genes with radical amino acid substitutions (Grantham matrix score >150)

PANTHER term

Genes

Percentage of total

Fold enrichment

P-value


MF00002:G-protein coupled receptor

36

9.7

2.2

1.50E-03

MF00001:Receptor

50

13.4

1.7

4.10E-02

MF00224:KRAB box transcription factor

20

5.4

2.8

4.50E-03


Values were calculated using the Database for Annotation, Visualization and Integrated Discovery (DAVID) web-based tools [24,25]. The background gene list used to determine enrichment is all genes in the mouse genome. The P-value refers to the enrichment P-value, which is a modified Fisher's exact test. A Bonferroni multiple testing correction has been applied.

Wong et al. Genome Biology 2012 13:R72   doi:10.1186/gb-2012-13-8-r72

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