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Open Access Method

A computational framework for boosting confidence in high-throughput protein-protein interaction datasets

Raghavendra Hosur1, Jian Peng12, Arunachalam Vinayagam3, Ulrich Stelzl4, Jinbo Xu2, Norbert Perrimon35, Jadwiga Bienkowska6* and Bonnie Berger17*

Author Affiliations

1 Computer Science and Artificial Intelligence Laboratory, 32 Vassar Street, MIT, Cambridge, MA 02139, USA

2 Toyota Technological Institute, 6045 S. Kenwood Ave, Chicago, IL 60637, USA

3 Department of Genetics, 77 Avenue Louis Pasteur, Harvard Medical School, Boston, MA 02115, USA

4 Otto-Warburg Laboratory, Ihnestraβe 63-73, Max Planck Institute for Molecular Genetics, Berlin D14195, Germany

5 Howard Hughes Medical Institute, 20 Shattuck Street, Boston, MA 02115, USA

6 Computational Biology group, Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA

7 Department of Mathematics, 77 Massachusetts Avenue, MIT, Cambridge, MA 02139, USA

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Genome Biology 2012, 13:R76  doi:10.1186/gb-2012-13-8-r76

Published: 31 August 2012

Additional files

Additional file 1:

Supplementary methods on the algorithm, results on benchmarking and comparison with other methods.

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