Functional insights from predicted interface. (a) Predicted interface for the interaction between BRAF (light blue) and PAK2 (red surface). Cancer-associated mutations that are annotated are shown in magenta. In dark blue we indicate mutations that are predicted to be associated with cancer but with no current annotations. The rest of the template structure is shown in gray. Mutations were taken from MoKCa database . (b) Predicted interface for the interaction between MAPK6 (yellow) and YWHAZ (cyan). Phosphorylation sites on the proteins are indicated in red (S189 for MAPK6 and S184 for YWHAZ). The template used for the prediction was 1F5Q (chains A and B).
Hosur et al. Genome Biology 2012 13:R76 doi:10.1186/gb-2012-13-8-r76