Individual variation of the binding sites for 15 Drosophila and 36 human TFs selected for this study. (a) Distributions of position-wise diversity at motif positions (red), scrambled motifs and motif flanks at the TF-bound regions of Drosophila (left panel) and human (right) TFs; P-values are from Kruskal-Wallis non-parametric significance tests. (b) Violin plots (a combination of boxplots and two mirror-image kernel density plots) showing the correlation between individual variation and information content per motif position for the bound instances of Drosophila (left) and human (right) TFs included in this study (top, red) and their scrambled versions detected within the same bound regions (bottom, grey); P-values are from Wilcoxon two-sample non-parametric significance tests.
Spivakov et al. Genome Biology 2012 13:R49 doi:10.1186/gb-2012-13-9-r49