Figure 8.

Two modes of TCF7L2-mediated transcriptional repression of GATA3 target genes. (a) GATA3 tethers TCF7L2 to the genome and both factors cooperate to repress target genes. (b) GATA3 tethers TCF7L2 to the genome with TCF7L2 antagonizing GATA3-mediated transcriptional activation.

Frietze et al. Genome Biology 2012 13:R52   doi:10.1186/gb-2012-13-9-r52