Table 3

TCF7L2 cell type-specific modules

Cell line

Top four co-localized motifs


HCT116

AP1, CTCF, NF-E2, SP1

HEK293

HOXC9, CDX2, PDX1, FOXA1

HepG2

HNF4α, FOXA2, ERRα, PPARγ

HeLa-S3

ERG, MAZ, CEBP, NF-E2

MCF7

GATA3, AP2, TEAD, AP1

PANC1

CDX2, FOXA1, TEAD, RUNX2


The sets of TCF7L2 binding sites specific for each cell line (not found in any of the other five cell lines) were analyzed using HOMER. The top four most highly enriched motifs (as determined by P-value), not including the TCF7L2 motif, are shown for each cell line.

Frietze et al. Genome Biology 2012 13:R52   doi:10.1186/gb-2012-13-9-r52

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