Table 1

Mutations that reduce growth control by pHc

Category

Gene

ORF

Absolute pHca

GO process


Inositol polyphosphates

PLC1

YPL268W

6.92 (0.035)

Inositol phosphate biosynthetic process

KCS1

YDR017C

6.76 (0.047)

Inositol phosphate biosynthetic process

Signal transduction

LCB5

YLR260W

6.99 (0.034)

Calcium-mediated signaling

RHO5

YNL180C

7.02 (0.025)

Rho protein signal transduction

Lipid synthesis

CAX4

YGR036C

6.93 (0.057)

Lipid biosynthetic process

PDX3

YBR035C

6.99 (0.025)

Fatty acid metabolic process

Vesicular transport

RGP1

YDR137W

6.92 (0.031)

Retrograde transport, endosome to Golgi

CLC1

YGR167W

7.01 (0.049)

Endocytosis

Mitochondria

RSM24

YDR175C

7.01 (0.024)

Mitochondrial translation

MRPL27

YBR282W

7.00 (0.019)

Mitochondrial translation

MRPL16

YBL038W

6.97 (0.028)

Mitochondrial translation

MRPL37

YBR268W

6.98 (0.032)

Mitochondrial translation

MRPS5

YBR251W

7.00 (0.027)

Mitochondrial translation

Various

MSS2

YDL107W

7.00 (0.035)

Protein insertion

ILV1

YER086W

6.98 (0.035)

Isoleucine biosynthetic process

REF2

YDR195W

6.97 (0.072)

mRNA processing

CYC8

YBR112C

7.00 (0.032)

Chromatin remodeling

Unknown

AIM44

YPL158C

6.97 (0.024)

Biological process unknown


aWild-type pH average is 7.08 ± 0.05. Mutants were clustered according to pHc with respect to growth rate (Materials and methods) and grouped according to functionally related gene ontology (GO) processes.

Orij et al. Genome Biology 2012 13:R80   doi:10.1186/gb-2012-13-9-r80

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