Table 1 |
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|
Mutations that reduce growth control by pHc |
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|
Category |
Gene |
ORF |
Absolute pHca |
GO process |
|
|
||||
|
Inositol polyphosphates |
PLC1 |
YPL268W |
6.92 (0.035) |
Inositol phosphate biosynthetic process |
|
KCS1 |
YDR017C |
6.76 (0.047) |
Inositol phosphate biosynthetic process |
|
|
Signal transduction |
LCB5 |
YLR260W |
6.99 (0.034) |
Calcium-mediated signaling |
|
RHO5 |
YNL180C |
7.02 (0.025) |
Rho protein signal transduction |
|
|
Lipid synthesis |
CAX4 |
YGR036C |
6.93 (0.057) |
Lipid biosynthetic process |
|
PDX3 |
YBR035C |
6.99 (0.025) |
Fatty acid metabolic process |
|
|
Vesicular transport |
RGP1 |
YDR137W |
6.92 (0.031) |
Retrograde transport, endosome to Golgi |
|
CLC1 |
YGR167W |
7.01 (0.049) |
Endocytosis |
|
|
Mitochondria |
RSM24 |
YDR175C |
7.01 (0.024) |
Mitochondrial translation |
|
MRPL27 |
YBR282W |
7.00 (0.019) |
Mitochondrial translation |
|
|
MRPL16 |
YBL038W |
6.97 (0.028) |
Mitochondrial translation |
|
|
MRPL37 |
YBR268W |
6.98 (0.032) |
Mitochondrial translation |
|
|
MRPS5 |
YBR251W |
7.00 (0.027) |
Mitochondrial translation |
|
|
Various |
MSS2 |
YDL107W |
7.00 (0.035) |
Protein insertion |
|
ILV1 |
YER086W |
6.98 (0.035) |
Isoleucine biosynthetic process |
|
|
REF2 |
YDR195W |
6.97 (0.072) |
mRNA processing |
|
|
CYC8 |
YBR112C |
7.00 (0.032) |
Chromatin remodeling |
|
|
Unknown |
AIM44 |
YPL158C |
6.97 (0.024) |
Biological process unknown |
|
|
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|
aWild-type pH average is 7.08 ± 0.05. Mutants were clustered according to pHc with respect to growth rate (Materials and methods) and grouped according to functionally related gene ontology (GO) processes. |
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|
Orij et al. Genome Biology 2012 13:R80 doi:10.1186/gb-2012-13-9-r80 |
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